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Yilei Zhao

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biology

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biology

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Molecular pathology is an emerging discipline within pathology which is focused in the study and diagnosis of disease through the examination of molecules within organs, tissues or bodily fluids.	分子病理学是病理学中的一门新兴学科，它的重点在于通过对器官、组织或体液中的分子进行检测从而达到疾病研究和诊断的目的。
Molecular pathology shares some aspects of practice with both anatomic pathology and clinical pathology, molecular biology, biochemistry, proteomics and genetics, and is sometimes considered a "crossover" discipline.	分子病理学在实践上与解剖病理学、临床病理学、分子生物学、生物化学、蛋白质组学和遗传学有一些共性，它有时被认为是一门“交叉”学科。
It is multi-disciplinary in nature and focuses mainly on the sub-microscopic aspects of disease.	它本质上具有多学科的特性，重在从亚显微层面看待疾病。
A key consideration is that more accurate diagnosis is possible when the diagnosis is based on both the morphologic changes in tissues (traditional anatomic pathology) and on molecular testing.	一个关注的重点是，当诊断是基于组织的形态改变（即传统的解剖病理学）和分子检测而作出时，诊断结果可能更精确。
It is a scientific discipline that encompasses the development of molecular and genetic approaches to the diagnosis and classification of human diseases, the design and validation of predictive biomarkers for treatment response and disease progression, the susceptibility of individuals of different genetic constitution to develop disorders.	它是一门集合了人类疾病诊断分类的分子和遗传学方法的最新发展，用于预测治疗反应、疾病进程的生物标志物的设计和验证，以及不同遗传体质个体发生疾病易感性的科学学科。
Molecular pathology is commonly used in diagnosis of cancer and infectious diseases.	分子病理学常用于癌症和传染性疾病的诊断。
Techniques are numerous but include quantitative polymerase chain reaction (qPCR), multiplex PCR, DNA microarray, in situ hybridization, in situ RNA sequencing, DNA sequencing, antibody based immunofluorescence tissue assays, molecular profiling of pathogens, and analysis of bacterial genes for antimicrobial resistance.	它涉及到的技术有很多，包括定量聚合酶链式反应（qPCR），多重PCR，DNA微阵列，原位杂交，原位RNA测序，DNA测序，基于抗体的免疫荧光组织分析，病原分子图谱分析和细菌耐药抗性基因分析。

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October 2025

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May 19, 2021

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